PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION

摘要

A pyrimidine derivative having an angiotensin (II) antagonism and represented by general formula (I), wherein A represents (I-1) or (I-2), R<1> and R<2> represent each hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, halogen or optionally substituted phenyl; R<3> and R<4> represent each hydrogen, alkyl, alkoxy, halogen, nitro, sulfone, carboxy, alkoxycarbonyl, cycloalkoxycarbonyloxyalkoxycarbonyl, alkanoyloxy alkoxycarbonyl or optionally protected tetrazolyl, or R<3> and R<4> may be combined together to form a fused 5- or 6-membered ring which may be substituted; X represents O, NH or S(O)p; p represents an integer of 0 to 2; m represents 1 or 2; B represents carboxy, alkoxycarbonyl or optionally protected tetrazolyl; and n represents 1 or 2.