| 摘要 |
A stabilized conjugated peptide complex comprising a peptide conjugatively coupled to a polymer including lipophilic and hydrophilic moieties, wherein the peptide may be insulin, calcitonin or an enzyme. In a particular aspect, the invention comprises an insulin composition suitable for parenteral, as well as non-parenteral administration, comprising insulin covalently coupled with a polymer including a linear polyalkylene glycol moiety and a lipophilic moiety, wherein the insulin, the linear polyalkylene glycol moiety and the lipophilic moiety arc conformationally arranged in relation to one another such that the insulin in the composition has an enhanced in vivo resistance to enzymatic degradation relative to insulin alone. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic or diagnostic, as shown in the figure.
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