N'-HETEROCYCLYL-N-BENZOFURANYL UREA DERIVATIVES AND THEIR ANALOGS AS ACAT INHIBITORS

摘要

This invention relates to new urea derivatives having an inhibitory activity against acyl-CoA:cholesterol acyltransferase enzyme and represented by general formula (I), wherein R<1> is a heterocyclic group which may be substituted with lower alkyl, etc., R<2> is lower alkyl, etc., R<3> is hydrogen, lower alkyl or aryl which may be substituted with halogen, etc., R<4> is hydrogen, halogen, lower alkyl, lower alkoxy or acyl which may be substituted with halogen, R<5> is aryl, etc., A is a single bond, etc., and X is O, etc., provided that at least one of unsubstituted or substituted aryl for R<3>, R<4> and R<5> is aryl except phenyl or substituted aryl, and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.