发明名称 |
NEW CENTRALLY ACTING 5-, 6-, 7-, AND 8-SUBSTITUTED SULPHONE ESTERS OF N-MONOSUBSTITUTED 2-AMINOTETRALINS AND RELATED STRUCTURES |
摘要 |
A compound of formula (1) or pharmaceutically acceptable acid addition salts thereof, wherein R1 is H, (C1-C8) alkyl, alkenyl, alkynyl, cyclopropylalkyl or (C1-C8) haloalkyl; X is CH2, O or S; R2-SO2-O is in position 5, 6, 7 or 8 and R2 is CF3, CF2CF3, C1-C8 alkyl, substituted aryl (e.g. 4-toluyl); R3 is H, CH3 or CH2CH3. When R3 is CH3 or CH2CH3, it is always in a cis-relationship with respect to the 2-amine substituent. |
申请公布号 |
WO9426703(A1) |
申请公布日期 |
1994.11.24 |
申请号 |
WO1994SE00465 |
申请日期 |
1994.05.18 |
申请人 |
DAMSMA-BLOEM, ANETTE, J. +HF;DAMSMA, ANNA +HF;DAMSMA, THIJS +HM;DAMSMA, MIRIAM +HF;WIKSTROEM, HAAKAN, VILHELM;BARF, TJEERD, ANDRIES;DIJKSTRA, DURK |
发明人 |
WIKSTROEM, HAAKAN, VILHELM;BARF, TJEERD, ANDRIES;DIJKSTRA, DURK;DAMSMA, GEERT +DI |
分类号 |
C07C309/65;C07C309/66;C07C309/73;C07D311/58;C07D335/06;(IPC1-7):C07C309/63;A61K31/13;A61K31/35;A61K31/38 |
主分类号 |
C07C309/65 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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