| 摘要 |
Process for the preparation of complexes of iodine with chitosan or derivatives thereof, and the iodinated compounds thus obtainable. Said compounds take fonn of powders, which may contain over 60 % of iodine in its elementary form. In a dry state the iodine bound to the chitosan or derivatives thereof does not sublimate. If the percentage content of iodine does not exceed 50 % (by weight), said powders can be dissolved in aqueous solvents of an acid type, such as, for example, diluted acetic acid or glutanic acid. Said solutions are compatible with addition of sufractants, preferably of a non-ionic type, which improve the solubility of the chitosan-iodine complex. Solutions with identical characteristics can, alternatively, be prepared by solubilizing, heating if necessary the iodine in a suitable sufractant, preferably non-ionic, and adding this solution under rapid stirring to the chitosan derivatives thereof, dissolved in water, optionally in the presence of acids or salts. Alternatively, the chitosan or derivatives thereof in a dry state can be added to the solution of iodine in surfactant which rapidly absorbs onto the solid, forming the chitosan-iodine complexes. This material suspended in water or in acid solutions, preferably acetic acid or glutamic acid, solubilizes rapidly. The complexes of iodine with chitosan or derivatives thereof, in the form of aspersable powders, solutions or ointments thanks to their disinfectant and cicatrizing properties, can be used in the field of surgery post-operative treatment and more generally speaking as products for topical use for medication of wounds and disinfection of the skin. Another area of interest in which the complexes can be used as an active principle is the field of cosmetics.
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