BICYCLOPOLYAZAMACROCYCLOPHOSPHONIC ACID COMPLEXES, A PROCESS FOR THEIR PREPARATION, AND THEIR CONJUGATES, FOR USE AS RADIOPHARMACEUTICALS

摘要

Complexes of bicyclopolyazamacrocyclophosphonic acid compounds with a metal ion, e.g. ?153Sm, 177Lu, 159Gd, 149Pm, 140La, 175Yb, 166Ho, 90Y, 47Sc, 186Re, 188Re, 142Pr, 99mTc, 67Ga, 68Ga, 105Rh, 97Ru, 111In, 113mIn or 115m¿In ion, are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complexes and conjugates are useful as radiopharmaceutical agents for therapy and/or diagnostic purposes. Processes for preparing the complex and conjugate are discussed.