PRODUCTION OF OPTICALLY ACTIVE NORSTATIN DERIVATIVE

摘要

PURPOSE:To stereoselectively produce an optically active norstatin derivative useful as an intermediate for various renin inhibitors, HIV protease inhibitors and carcinostatic agents from a cyanohydrin derivative or an aldehyde derivative using an enzyme. CONSTITUTION:An optically active norstatin derivative is stereoselectively produced from a cyanohydrin derivative or an aldehyde derivative using a nitrile hydrolase.