PRODUCTION OF (2S,4AR,6S,8S,8AS)-1,2,4A,5,6,7,8,8A-OCTAHYDRO-2-METHYL-6((E)-1-PROPENYL)NAPHTHALENE DERIVATIVE

摘要

PURPOSE:To simply obtain the subject compound useful as a synthetic intermediate for HMG-CoA reductase inhibitor having decalin skeleton by irradiating Z configuration based on propenyl group at the 6-position of a naphthalene derivative with light rays. CONSTITUTION:Z Configuration based on propenyl group at the 6-position of a (2S,4aR,6S,8aS)-1,2,4a,5,6,7,8,8a-octahydro-2-methyl-6-((e)-l-propenyl )naphthalene derivative of formula I [R<1> is H, OH-protecting group; 2-6C alkanoyl or aroyl; R<2> is oxycarbonyl of COOR<3> (R<3> is H, 1-5C alkyl, etc.) or oxymethyl of CH2OR<4> (R<4> is H or OH-protecting group)] is irradiated with light rays by using a high- pressure mercury vapor lamp in the presence of a radical initiator (e.g. diphenyl disulfide) in a solvent (e.g. benzene) to give the objective compound of formula II.