发明名称 |
Localized delivery using fibronectin conjugates |
摘要 |
This invention encompasses new and substantially improved methods and compositions for delivery of therapeutic agents to specifically chosen body sites. Conjugation of fibronectin to bioactive agents or to lipids or to liposomes which entrap the bioactive agents permits immobilization of the bioactive agent when administered at collagen-, heparin-, hyaluronic acid-, fibrin/fibrinogen-, or ganglioside-rich sites. Covalent conjugation is achieved by two methods: (1) the enzymatically catalyzed cross-linkage of fibronectin to an amine containing compound, and (2) by a modified NHS method which permits formation of peptide bonds between fibronectin and lipid compounds.
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申请公布号 |
US5366958(A) |
申请公布日期 |
1994.11.22 |
申请号 |
US19930110193 |
申请日期 |
1993.08.20 |
申请人 |
THE LIPOSOME COMPANY, INC. |
发明人 |
WEINER, ALAN L.;LENK, ROBERT P.;CARPENTER-GREEN, SHARON S.;FOUNTAIN, MICHAEL W. |
分类号 |
A61K9/127;A61K9/133;A61K47/48;(IPC1-7):A61K37/02;C07K7/02 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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