N-acyl-substituted azacyclic compounds, processes for their preparaion, and their use as pharmaceuticals

摘要

PCT No. PCT/EP90/01961 Sec. 371 Date May 22, 1992 Sec. 102(e) Date May 22, 1992 PCT Filed Nov. 14, 1990 PCT Pub. No. WO91/08205 PCT Pub. Date Jun. 13, 1991.A compound, a solvate or salt thereof, of formula (I): <IMAGE> (I) in which: A is <IMAGE> or <IMAGE> p is 2; ROC- is an acyl group linked to a substituted or unsubstituted carbocyclic aromatic ring system; R1 and R2 are substituents on the same or different carbon atoms and are independently hydrogen or C1-6 alkyl; and Ra is a phenyl or thienyl ring, and is useful for the treatment of pain, hyponatremic disease states or cerebral ischemia.