发明名称 |
Preparation and uses of LOS-depleted outer membrane proteins of gram-negative cocci. |
摘要 |
Described herein is a method for removing toxic lipooligosaccharide (LOS) from outer membranes of Gram-negative cocci, such as Neisseria meningitidis. LOS-depleted outer membranes and LOS-depleted soluble outer membrane proteins can be prepared, which are able to elicit bactericidal antibodies against homologous strains of bacteria. Vaccines and other uses of the preparations are further described. |
申请公布号 |
EP0624376(A1) |
申请公布日期 |
1994.11.17 |
申请号 |
EP19940106827 |
申请日期 |
1994.05.02 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
ZLOTNICK, GARY W. |
分类号 |
C12P21/00;A61K39/00;A61K39/09;A61K39/095;A61K39/395;A61P31/04;C07K14/195;C07K14/22;C07K14/41;C07K16/14;C12R1/36 |
主分类号 |
C12P21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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