| 摘要 |
NEW MATERIAL:The amide derivative of formula I (R<1> and R<2> are straight- or branched-chain saturated or unsaturated hydrocarbon group; the carbon numbers of R<1> and R<2> are 10-26 and 9-25, respectively; X-Z are H, 1-5C alkyl or hydroxyalkyl; X, Y and Z are not H at the same time). EXAMPLE:N-(2-hydroxy-3-hexadecyloxypropyl)-N-2, 3-dihydroxypropyl-hexadeca namide. USE:An active component for external drug for skin exhibiting excellent ameliorating and preventive effect against chapped skin owing to the radically improving effect of the compound on the water-retaining capability of cuticle layer. PREPARATION:The compound of formula I can be produced by acylating a compound of formula II derived from a compound of formula III and a compound of formula IV and selectively hydrolyzing the ester group of the resultant compound of formula V. The above effect can be further improved by the combined use of the compound with a surfactant. |
