发明名称 |
Genetically engineered vaccine strain |
摘要 |
What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
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申请公布号 |
US5364773(A) |
申请公布日期 |
1994.11.15 |
申请号 |
US19930036217 |
申请日期 |
1993.03.24 |
申请人 |
VIROGENETICS CORPORATION |
发明人 |
PAOLETTI, ENZO;PERKUS, MARION E. |
分类号 |
A61K39/00;C07K14/015;C07K14/02;C07K14/03;C07K14/035;C07K14/045;C07K14/05;C07K14/06;C07K14/065;C07K14/07;C07K14/11;C07K14/12;C07K14/125;C07K14/145;C07K14/15;C07K14/155;C07K14/16;C07K14/175;C07K14/18;C07K14/33;C12N15/863;(IPC1-7):C12P21/02;C12P19/34;C12N15/00;C12N7/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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