New thiazole derivatives, and pharmaceutical composition comprising the same

摘要

A compound of the formula: <IMAGE> wherein R1 is amino, ureido, lower alkanoylamino, lower alkoxycarbonylamino, lower alkylsulfonylamino, lower alkoxy(lower)alkanoylamino, mono or di or trihalo(lower)alkanoylamino, hydroxy(lower)alkanoylamino, protected hydroxy(lower)alkanoylamino, or a group of the formula: <IMAGE> in which R4 is hydrogen or sulfamoyl, R5 is amino or lower alkoxy, R2 is hydrogen, lower alkyl, lower alkoxy(lower)alkyl, di(lower)alkylamino(lower)alkyl, (C3-C7)-cycloalkyl, lower alkenyl or mono or di or trihalo(lower)alkyl; R3 is hydrogen or lower alkyl; or R2 and R3 are linked together to form lower alkylene, Y is <IMAGE> in which R6 is hydrogen, A is lower alkylene, and W is NH; or R2-W is piperidino or morpholino, or pharmaceutically acceptable salt thereof.