SOLID FORM OF ADMINISTRATION OF ISOSORBIDE 5-MONONITRATE
摘要
A solid form of oral administration of isosorbide 5-mononitrate with a controlled, pH-independent release of the active substance in the gastro-intestinal tract is constituted by a pellet coated with a depot layer and a release prolonging lacquer layer. The lacquer layer contains ethyl cellulose and polymethacrylate in a weight ratio from 3:1 to 3:2. The new form of administration is characterized in that it is less costly to produce.
申请公布号
WO9425010(A1)
申请公布日期
1994.11.10
申请号
WO1994EP01268
申请日期
1994.04.23
申请人
BYK NEDERLAND BV;VAN EGMOND, CORNELIA, ALIDA, MARIA;PULLEN, ANDRE;DE JONG, SIBO, WYTSE;DE JONG, ADRIANUS, PETRUS;BRON, JAN
发明人
VAN EGMOND, CORNELIA, ALIDA, MARIA;PULLEN, ANDRE;DE JONG, SIBO, WYTSE;DE JONG, ADRIANUS, PETRUS;BRON, JAN