This invention relates to the inhibition of intercellular adhesion mediated by L-selectin by administering a newly identified L-selectin ligand, CD34. More particularly, the invention concerns a method for inhibiting leukocyte adhesion to endothelial cells by administering an effective amount of an isolated, purified CD34 polypeptide or an antibody capable of binding native CD34.
申请公布号
WO9425047(A1)
申请公布日期
1994.11.10
申请号
WO1994US03791
申请日期
1994.04.06
申请人
GENENTECH, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;LASKY, LAURENCE, A.;BAUMHUETER, SUSANNE;ROSEN, STEVEN, D.;SINGER, MARK, S.
发明人
LASKY, LAURENCE, A.;BAUMHUETER, SUSANNE;ROSEN, STEVEN, D.;SINGER, MARK, S.
