Antineoplastic taxol derivatives are derived by selective oxidation of the alkene portion of the side chain of cephalomannine. The derivative displays high activity in promoting assembly of microtubulin and also displays cytotoxic activity against malignant cells.
申请公布号
WO9425449(A1)
申请公布日期
1994.11.10
申请号
WO1994US04519
申请日期
1994.04.25
申请人
HAUSER CHEMICAL RESEARCH, INC.
发明人
MURRAY, CHRISTOPHER, K.;BECKVERMIT, JEFFREY, T.;ZIEBARTH, TIMOTHY, D.
