| 摘要 |
<p>The food intake by animals, including humans, can be influenced by administering a suitable dose of simmondsine. The appetite is hereby inhibited and weight loss effected. The simmondsine can be administered as such or in the form of de-oiled jojoba flour. Derivatives and/or analogues of simmondsine can further be applied such as simmondsine-2'-ferulate or aglucons of simmondsine. A suitable method for isolating and purifying simmondsine (and/or analogues thereof) comprises: extracting de-oiled jojoba flour (preferably with acetone), fractionating the extract by means of adsorption chromatography, filtering the fractions containing the simmondsine, fractionating the filtrate again by means of adsorption chromatography and crystallizing the simmondsine from the obtained fractions. Practical applications of the invention relate particularly to reduction of the food intake in mother animals of livestock for fattening in addition to stimulating recuperation growth in animals for slaughter, in diets for pets etc.</p> |
