| 摘要 |
<p>Cephalosporin derivatives of the general formula <IMAGE> wherein R<1> is an acyl group derived from carbolic acid; R<2> is hydrogen, hydroxy, lower alkyl-Qm, cylcoalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aralkyl-Qm, aryl-Qm, aryloxy, aralkoxy or a heterocyclic ring, the lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aralkyl, aryl, aryloxy, aralkoxy and the heterocyclic ring being unsubstituted or substituted with at least one group selected from carboxy, amino, nitro, cyano, lower alkyl, lower alkoxy, hydroxy, halogen, -CONR<4>R<5>, -N(R<5>)COOR<9>, R<5>CO-, R<5>OCO- or R<5>COO- where R<4> is hydrogen, lower alkyl, or cycloalkyl; R<5> is hydrogen or lower alkyl; R<9> is hydrogen, lower alkyl, lower alkenyl or a carboxylic acid protecting group; Q is -CO- or -SO2-; m is 0 or 1; n is 0, 1, or 2; as well as readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their esters and salts, are antibacterially active. Novel intermediates which are corresponding amines or protected derivatives are also described.</p> |
