| 摘要 |
The present invention relates to highly diastereoselective synthesis of optically active cis-nucleosides and their analogues and derivatives of general formula (I) wherein W is S, sulphinyl or sulphonyl or O, X is S, sulphinyl, sulphonyl or O; R1 is H of acyl; and R2 is the rest of purin or pyrimidine alkali present in nucleosides in nature or its analogue or derivative, glycolysation of required purin of pyrimidine alkali or its analogue or derivative by intermediate of general formula (IIA) or (II B), wherein R3 is substituted carbonyl or its derivative and L is outgoing group by using Lewis acid.
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