NEW ARENO[e]INDOLS, PREPARATION METHOD AND APPLICATION AS INTERMEDIATES IN THE SYNTHESIS OF PRODUCTS WITH ANTITUMORAL ACTIVITY.

摘要

The areno(e)indols have the formula (I). The methods comprises: (a) reacting (VI) with an aldehyde Ar''-CHO to obtain (VII); (b) oxidizing (VII) to yield the cetone (VIII); (c) reating (VIII) with a strong base and thereafter with an acyle chloride CICOR, to produce (IX); (d) subjecting to a photochemical cyclization (IX) to produce (I). In said formulas Ar is phenyl or substituted phenyl; Ar' is a radical (i) or )ii); R is an acyle group, Ar'' is a phenyl, pyrolyl, furanyl or thiophenyl group substituted up to three times by any of the radicals R, R<1>, R<2>, or R<3>. The compounds (I) are useful as intermediates in the synthesis of hexahydroareno(e)cyclopropa(c)indol-4-ones with antitumoral activity.