发明名称 |
Production of recombinant factor xa inhibitor of leech hirudo medicinalis |
摘要 |
The present invention provides a recombinant polypeptide having the amino acid sequence X-tyr26-gly110 where tyr26-gly110 is identical to the sequence shown in FIG. 10, and wherein X is methionine or absent and wherein asn72 may be substituted by pro. The invention further provides a method of producing the polypeptide which comprises transforming a host cell with an expression plasmid encoding the polypeptide, culturing the transformed host cell so that the cell produces the polypeptide encoded by the plasmid, and a method of recovering the polypeptide so produced. |
申请公布号 |
AU6630294(A) |
申请公布日期 |
1994.11.08 |
申请号 |
AU19940066302 |
申请日期 |
1994.04.08 |
申请人 |
BIO-TECHNOLOGY GENERAL CORP.;YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF |
发明人 |
MOSHE M WERBER;ELISHA P ZEELON;AVIGDOR LEVANON;RACHEL GUY;ARIE GOLDLUST;MEIR RIGBI;AMOS PANET;MEIR FISCHER |
分类号 |
C12N15/09;A61K38/00;A61K38/45;A61K38/46;A61P7/02;A61P31/12;A61P43/00;C07K1/16;C07K14/815;C07K16/38;C12N1/21;C12N9/99;C12N15/15;C12P21/02;C12P21/08;C12R1/19 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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