| 摘要 |
Therapeutic compounds with at least one ring-substituted side chain have the formula: CORE MOIETY -- (R)j. j is an integer from one to three, the core moiety is non-cyclic or cyclic, and R is selected from the group consisting of hydrogen, halogen, hydroxyl, amino, substituted or unsubstituted C(1-10) alkyl, C(2-10) alkenyl, cyclic or heterocyclic groups and formula (I), wherein n is an integer from one to twenty and m and p are independently zero or an integer from one to twenty. R1 is selected from the group consisting of hydrogen, halogen, hydroxide, and substituted or unsubstituted C(1-10) alkyl, C(1-10) alkoxy, C(2-10) alkenyl, and a ring group having at least one four- to seven-membered ring; R2 is selected from the group consisting of hydrogen, halogen, hydroxide, substituted or unsubstituted C(1-10) alkyl, C(1-10) alkoxy and C(2-10) alkenyl; and R3 is selected from the group consisting of hydrogen or a substituted or unsubstituted ring group having at least one four- to seven-membered ring. At least one of R1 or R3 is the ring group and a sum of either (n+m) or (n+p), corresponding to a respective R1 or R3 ring group is not greater than nineteen. The compounds and pharmaceutical compositions thereof are useful as therapies for diseases advanced via intracellular signaling through specific intracellular signaling pathways by mediating a signaling response to an external stimuli. |
