| 发明名称 |
Farnesyl pyrophosphate analogs |
| 摘要 |
The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention, and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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| 申请公布号 |
US5362906(A) |
申请公布日期 |
1994.11.08 |
| 申请号 |
US19930079661 |
申请日期 |
1993.06.18 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
ANTHONY, NEVILLE J.;LEE, TA-JYH;SMITH, ROBERT L.;STOKKER, GERALD E. |
| 分类号 |
C07F9/24;C07C43/30;C07C45/29;C07C47/21;C07C59/42;C07C233/04;C07C233/05;C07F9/38;C07F9/40;(IPC1-7):A01N47/10;C07C229/00 |
主分类号 |
C07F9/24 |
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