| 摘要 |
PCT No. PCT/FI94/00136 Sec. 371 Date Sep. 19, 1995 Sec. 102(e) Date Sep. 19, 1995 PCT Filed Apr. 12, 1994 PCT Pub. No. WO94/23770 PCT Pub. Date Oct. 27, 1994An endo-osteal material which includes an endo-osteal material treated with a solution of a bisphosphonate of formula (1) wherein X is H, OH, Cl, F or a methyl group and Y is Cl, OH, -(CH2)2-N(CH3)-(CH2)4-CH3, -(CH2)n-CH3 or -(CH2)n-NH2, where n is zero or an integer being 1 to 8, -NHZ, where Z is pyridinyl or cycloheptyl, SZ', where Z' is pyridinyl or chlorosubstituted phenyl or Y is a pyridinylsubstituted lower alkyl chain; or a non-toxic, pharmaceutically acceptable salt or ester thereof dissolved in an appropriate solvent. <IMAGE> |
