| 发明名称 |
Alkyl phosphonate polyazamacrocyclic cheates for MRI |
| 摘要 |
The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses as a tissue specific chelator. The compound has the formula <IMAGE> where x is 2, 3 or a combination of p 2(s) and q 3(s) where p+q=y; y is 4; R is ( CH2)zP(=0)OR1OR2; R1 is H or CH3; R2 is CnH1+2n; n is 4 to 6; z is 1 to 3. M is a heavy metal ion. These compounds may be used for magnetic resonance imaging.
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| 申请公布号 |
US5362476(A) |
申请公布日期 |
1994.11.08 |
| 申请号 |
US19920923715 |
申请日期 |
1992.07.31 |
| 申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;DOW CHEMICAL COMPANY |
发明人 |
SHERRY, A. DEAN;KIEFER, GARRY E. |
| 分类号 |
A61K49/00;A61K49/04;A61K49/06;A61K51/00;A61K51/04;C07D255/02;C07D257/02;C07D259/00;C07F9/6515;C07F9/6524;(IPC1-7):A61B5/055;A61B31/675;C07D225/00 |
主分类号 |
A61K49/00 |
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