| 摘要 |
An anti-allergic agent is disclosed which comprises a human monoclonal antibody which binds to an airborne allergen that provokes an allergic IgE response, an allergen-binding fragment of such human monoclonal antibody or an immune complex of such human monoclonal antibody or allergen-binding fragment with said allergen. Pharmaceutical compositions and methods employing the anti-allergic agent, cell lines for making the human monoclonal antibodies and purified and isolated DNA for making the human monoclonal antibodies or allergen-binding fragments thereof are also disclosed. Also disclosed is a process for making multiple clones from an immortalized B-cell population, each of which clones secretes a human monoclonal antibody that binds to the desired antigen. |
