PROCESS FOR PRODUCING 1-FLUORO-GLYCURONIC ACIDS AND THEIR SALTS AND SUCH NEW 1-FLUORO-GLYCONIC ACIDS AND THEIR SALTS.

摘要

HOE 89/F 149 of the disclosure: Process for the preparation of 1-fluoro-glycuronic acids and salts thereof, and such novel 1-fluoro-glycuronic acids and salts thereof Process for the preparation of 1-fluoro-glycuronic acids, which can contain protected amino groups, and salts thereof, characterized in that glycopyranosyl fluorides of mono- or oligosaccharides which carry at least one primary OH function are oxidized with oxygen as the oxidizing agent in an aqueous solution in the pH range from 6 to 9 in the presence of a catalyst which contains at least one platinum metal, and the 1-fluoro-glycuronic acids formed are at least partly neutralized. The invention furthermore relates to compounds of the general formula (I) in which M represents hydrogen or a cation, in particular an alkali metal, and X denotes oxygen or NH, independently of one another, wherein, if X = oxygen, R denotes hydrogen or a glycosidically bonded monosaccharide and if X = NH, R represents an acyl, alkyl, aryl or aralkyl protective group radical having up to 10 carbon atoms, but wherein only one of the groups RX has a meaning other than OH.