Quinazolinones useful as endothelin antagonists

摘要

Quinazolinones with structural formula I have endothelin antagonist activity and are useful in treating e.g. cardiovascular disorders, hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.