| 摘要 |
PURPOSE:To obtain the compound useful as an intermediate for medicines, pesticides, etc., in a high yield, while reducing side reactions, by chlorinating an alkylmercaptan compound with a chlorinating agent in the presence of a catalytic amount of a quaternary salt in a two phase system comprising an organic solvent and water. CONSTITUTION:An alkyl mercaptan compound of formula I (R is alkyl, aralkyl; X is H, alkali metal) is chlorinated with a chlorinating agent in the presence of a catalytic amount of a quaternary salt in a two phase system comprising an organic solvent such as 1,2-dichloroethane and water to produce an alkylsulfonyl chloride of formula II (e.g. ethane sulfonyl chloride). The quaternary salt used in the reaction is preferably a quaternary ammonium salt such as tetramethyl ammonium or a quaternary phosphonium such as tetramethyl phosphonium chloride. The chlorinating agent is preferably chlorine or sulfuryl chloride. The quaternary salt is preferably used in an amount of 0.5-10wt.% based on the alkyl mercaptan compound of formula I. Since the reaction conditions of the method are mild, and since the amount of the used catalyst is a little, the method is industrially highly useful. |
