发明名称 |
IMMUNOMODULATOR, CELL ADHESION INHIBITOR, AND AGENT FOR TREATING AND PREVENTING AUTOIMMUNE DISEASES |
摘要 |
A 4H-1-benzopyran-4-one derivative of general formula [1], or a salt thereof exerts excellent effects of immunomodulation and cell adhesion inhibition, and is further expected to have the effect of relieving autoimmune diseases at a level comparable to that of steroids. Thus the compound of general formula [1] is useful in the treatment and prevention of autoimmune diseases fundamentally caused by immunopathy or abnormally accelerated cell adhesion, for example, chronic rheumatoid arthritis, systemic lupus erythematosus, sclerema, mixed connective tissue disease, polyarteritis nodosa, polymyositis/dermatomyositis, Sjögren's syndrome, Behcet's disease, multiple sclerosis, autoimmune diabetes, Hashimoto's disease, psoriasis, primary myxedema, pernicious anemia, serious adynamia, ulcerative colitis, chronic active hepatitis, autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura. |
申请公布号 |
WO9423714(A1) |
申请公布日期 |
1994.10.27 |
申请号 |
WO1994JP00585 |
申请日期 |
1994.04.07 |
申请人 |
TOYAMA CHEMICAL CO., LTD.;TANAKA, KEIICHI;MAKINO, SHINJI;OSHIO, ICHIRO;SHIMOTORI, TOMOYA;AIKAWA, YUKIHIKO;INABA, TAKIHIRO;YOSHIDA, CHOSAKU;TAKANO, SHUNTARO;TANIGUCHI, YOICHI |
发明人 |
TANAKA, KEIICHI;MAKINO, SHINJI;OSHIO, ICHIRO;SHIMOTORI, TOMOYA;AIKAWA, YUKIHIKO;INABA, TAKIHIRO;YOSHIDA, CHOSAKU;TAKANO, SHUNTARO;TANIGUCHI, YOICHI |
分类号 |
C07D311/22;C07D311/24;C07D311/26;(IPC1-7):A61K31/35;C07D407/12;C07D401/12;C07D407/04;C07D311/56;C07D311/54;C07D311/44;A61K31/445;A61K31/44;A61K31/41;A61K31/40;A61K31/38 |
主分类号 |
C07D311/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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