| 摘要 |
<p>A compound of formula (I) or a pharmaceutically acceptable salt thereof, where R<1> is hydrogen, R<1>a or a group of formula (II), R<1?>a< is R?1>b or a protecting group Q, R<1>b is C1-C20 alkyl, C2-C20 alkenyl, C3-C10 cycloalkyl, C6-C15 aryl, C7-C16 aralkyl or a 5- or 6- membered heterocyclic group attached by a carbon atom in the heterocyclic group to the indicated phosphorus atom, R<2> is hydrogen, R<2>a or -OR<15>, provided that when R<1> is hydrogen, R<2> is R<2>a or -OR<15>, R<2>a is a C1-C20 aliphatic group, a C3-C10 cycloaliphatic group, a C6-C15 aromatic group, a C7-C16 araliphatic group, or a 5- or 6- membered heterocyclic group attached by a carbon atom in the heterocyclic group to the indicated phosphorus atom, R<3> is hydrogen, halogen, hydroxy, R<16>, -OR<16>, OSO2R<16>, OCOR<16> or tri(C1-C15 hydrocarbyl) silyloxy, R<4> is R<4>a or together with R<6> denotes a valence bond, R<4>a is hydrogen, halogen or R<17>, R<5> is hydrogen, halogen, hydroxy, R<18>, -OR<18>, -OCOR<18>, OSO2R<18>, or tri(C1-C15 hydrocarbyl) silyloxy, R<6> is hydrogen, halogen or R<19>, or together with R<4> denotes a valence bond, R<7> is hydrogen, or an atom or group capable of terminating a replicating strand of a nucleic acid or of inhibiting viral DNA synthesis, other than a group connected to the indicated furanose ring through an oxygen atom, or together with R<8> denotes a valence bond, R<8> is R<8>a, or together with R<7> denotes a valence bond, R<8>a is hydrogen, halogen, hydroxy, R<20>, -OR<20>, -OCOR<20>, -OSO2R<20> or tri(C1-C15 hydrocarbyl) silyloxy, R<9> is a monovalent nucleoside base radical, R<10> is hydrogen or R<10>a, R<10>a is R<21>, -COR<21>, -SO2R<21> or tri(C1-C15 hydrocarbyl)silyl, R<11> is hydrogen, halogen, hydroxy, R<22>, -OR<22>, -OCOR<22>, -OSO2R<22> or Z, R<12> is hydrogen, halogen or R<23>. R<13> is hydrogen or R<13>a, R<13>a is halogen, hydroxy, R<24>, -OR<24>, -OCOR<24>, -OSO2R<24> or tri(C1-C15 hydrocarbyl)silyloxy, R<14> is a monovalent nucleoside base radical, R<15> is hydrogen or R<15>a, R<15>a is a C1 to C10 aliphatic group, a C3 to C8 cycloaliphatic group, a C6 to C15 aromatic group or a C7 to C16 araliphatic group, R<16>, R<17>, R<18>, R<19>, R<20>, R<21>, R<22>, R<23> and R<24> are independently a C1 to C10 aliphatic group, a C3 to C10 cycloaliphatic group, a C6 to C15 aromatic group or a C7 to C30 araliphatic group, and Z is substituted or unsubstituted C6 to C10 aryloxythiocarbonyloxy.</p> |
