发明名称 |
Stereoselective epoxidation of alkenes by chloroperoxidase |
摘要 |
A method of converting olefins to chiral epoxides comprises combining an asymmetric aliphatic or aryl alkene substrate with a buffered chloroperoxidase solution to form a stabilized reaction mixture, and gradually adding hydrogen peroxide as a substrate oxidant, such that the chloroperoxidase catalyzes the conversion of the substrate to the corresponding epoxide in enantiomeric excess. The products of the invention are alkyl and aryl non-primary epoxides. The resulting preparations are enantiomerically pure, and may greatly enhance large-scale synthesis of stereoisomer products such as pharmaceuticals and pesticides.
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申请公布号 |
US5358860(A) |
申请公布日期 |
1994.10.25 |
申请号 |
US19930043049 |
申请日期 |
1993.04.05 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS |
发明人 |
HAGER, LOWELL P.;ALLAIN, ERIC J. |
分类号 |
C07D301/12;C07D303/04;C12P17/02;(IPC1-7):C12N9/08 |
主分类号 |
C07D301/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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