| 摘要 |
PURPOSE:To provide the subject new compound obtained from the cultured product of a specific marine bacterium, exhibiting inhibiting actibn on cysteine protease and useful for the treatment of cerebral infarction, myocardial infarction, thrombosis, muscular dystrophy, osteoporosis, inflammation, cancer metastasis, etc. CONSTITUTION:A marine bacterium SANK70992 strain separated from Enteromorpha collected on the shore of Ojika peninsula, Miyagi Prefecture is inoculated to a sterilized medium and precultured at 26 deg.C for 3 days with a rotary shaker. The precultured product is transferred to a medium in a tank and cultured under stirring at 26 deg.C for 47hr and a fraction having inhibiting action on type II carpaine originated from bovine kidney is separated and purified to obtain the objective new compound B1371A or B1371B expressed by formula I or formula II exhibiting cysteine protease activity and useful as an anticerebral infarction agent, antimyocardial infarction agent, antithrombotic agent, antimuscular dystrophy agent, antiosteoporosis agent, anti-inflammation agent or cancer metastasis preventing agent. |
