发明名称 |
Hiv-1 vaccines, antibody compositions related thereto, and therapeutic and prophylactic uses thereof |
摘要 |
The subject invention provides a recombinant nucleic acid molecule which encodes a mutant HIV-1 gp120 envelope glycoprotein comprising a V3 loop deletion and a C4 domain(W->X) point mutation wherein X is an amino acid residue other than tryptophan, and the HIV-1 gp120 envelope glycoprotein encoded thereby. The subject invention further provides a method of obtaining partially purified antibodies which specifically bind to the CD4-binding domain of HIV-1 gp120 envelope glycoprotein, the partially purified antibodies produced thereby, and pharmaceutical compositions comprising same. Finally, the subject invention provides methods of treating HIV-1-infected subjects, and of reducing the likelihood of HIV-1-exposed and non-HIV-1-exposed subjects' becoming infected with HIV-1 using the pharmaceutical compositions of the subject invention. |
申请公布号 |
AU6525194(A) |
申请公布日期 |
1994.10.24 |
申请号 |
AU19940065251 |
申请日期 |
1994.03.25 |
申请人 |
PROGENICS PHARMACEUTICALS, INC. |
发明人 |
KARL W HASEL;PAUL J. MADDON |
分类号 |
A61K38/00;A61K39/00;A61P31/18;C07K14/16;C12N1/21;C12N15/49 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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