发明名称 Leukotriene B4 synthesis inhibitors
摘要 This invention relates to a compound of the formula: <IMAGE> or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, -CH=CH-, or -CH=N-; wherein R1 is -CO2R2or tetrazole; wherein R2 is hydrogen, alkyl of 1 to 6 carbons or a pharmaceutically acceptable cation; wherein R is an alkyl of from 1 to 20 carbons, -(CH2)pCF3 or -(CH2)qR3 wherein R3 is alkoxy, phenoxy or alkoxy substituted phenoxy wherein the alkoxy group has from 1 to 8 carbons; wherein p and q are integers from 0 to 20; wherein n is 0 or 1; and wherein m is 0, 1, 2, or 3.
申请公布号 US5356919(A) 申请公布日期 1994.10.18
申请号 US19910707522 申请日期 1991.05.30
申请人 G. D. SEARLE & CO. 发明人 DJURIC, STEVAN W.;HAACK, RICHARD A.;MIYASHIRO, JULIE M.
分类号 C07C43/215;C07C63/64;C07C63/66;C07C65/32;C07C65/34;C07C65/38;C07C65/40;C07D213/79;C07D257/04;C07D307/68;C07D333/38;C07F7/08;(IPC1-7):A61K31/41 主分类号 C07C43/215
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