GRANULARE ZUBEREITUNGEN UND VERFAHREN ZUR IHRER HERSTELLUNG.

摘要

Granulated preparations are provided by causing a granular, preferably spherical polyglycerol fatty acid ester having a melting point of 40-80 DEG C together with a powder for fluidized bed formation and heating the resulting fluidized mixture at a temperature in the vicinity of the melting point of the polyglycerol fatty acid ester. The powder may contain as least one pharmacologically active ingredient. The polyglycerol fatty acid ester shows no crystal polymorphism and does not inactivate the pharmacologically active ingredient. Furthermore, the dissolution and release of the pharmacologically active ingredient can be controlled by varying the HLB of the polyglycerol fatty acid ester.