A DETECTION AND QUANTITATION METHOD FOR THERAPEUTIC AGENTS IN BLOOD
摘要
The present invention relates to an improved method for the determination of therapeutic agents in blood. This method utilizes a solid phase extraction of the solute from plasma followed by reverse phase high performance liquid chromatography on a column of irregularly shaped C-18 modified silica. Comparison of the produced chromatogram with a standard curve provides a precise and accurate quantification of the amount of the solute in blood. Additionally, the extraction and chromatography steps can be readily automated for the rapid determination of multiple samples.
申请公布号
WO9423293(A1)
申请公布日期
1994.10.13
申请号
WO1994US03320
申请日期
1994.03.28
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS
发明人
KOHN, ELISE, C.;LIOTTA, LANCE, A.;CHAFFINS, SCOTT, A.