LIQUID ANTITHROMBIN III PREPARATION AND METHOD OF STABILIZING THE SAME
摘要
A liquid antithrombin III (AT-III) preparation comprising AT-III and a stabilizer such as an organic acid, a salt thereof, a sugar sulfate or a surfactant, and having a pH value of 9 to 10. It is stable even when stored for long and is clinically nonproblematic at all in respect of both the pharmacological effect and the safety. Further it is advantageous in that it can readily be administered because it need not be dissolved in distilled water for injection unlike dried preparations. Therefore this preparation is extremely useful from the clinical viewpoint.
申请公布号
WO9422471(A1)
申请公布日期
1994.10.13
申请号
WO1994JP00563
申请日期
1994.04.05
申请人
THE GREEN CROSS CORPORATION;URIYU, KATSUHIRO;OHMIZU, AKIMASA;FUKUYAMA, HAJIME;TAKECHI, KAZUO;YOKOYAMA, KAZUMASA