CYCLIC KETAL DERIVATIVES FOR THE TREATMENT OF ACNE

摘要

Compounds are described of formula (I), wherein R<1> represents a hydroxyl group or a group selected from OCOCH=CHCH(CH3)(CH2)3CH3, -OCOCH=CHC(CH3)=CHCH(CH3)CH2CH3 or -OCO-X-CH2CH(CH3)CH2CH3 [where X is -CH=CHCH(CH3)-, -CH2CH(OH)CH(CH3)-, -CH=CHC(OH)(CH3)-, -CH2CH(OH)CH2- or -CH2CH2CH(CH3)-]; R<2> represents a hydroxyl group; R<3> represents a group selected from (a) (where R<6> is a hydrogen atom or an acetyl group), -C(CH3)=CHCH(CH2R<7>)CH2Ph (where R<7> is a hydrogen or a hydroxyl group), -C(CH2OH)=CHCH(CH3)CH2Ph, -C(=CH2)CH(OH)CH(CH2OH)CH2Ph, -C(=CH2)CH(NHCOCH3)CH(CH3)CH2Ph, -C(CH2NHCOCH3)=CHCH(CH3)CH2Ph and (b); R<4> and R<5> may each independently represent a hydrogen atom or a methyl group; and salts thereof. These compounds inhibit the enzyme squalene synthase and may be formulated for use in the treatment of acne.