摘要 |
Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have formula (a) and (b), where A, A' = -SZ or Y, B = O or S, Y = (c), Z = H or a thiol protecting group, m = 2 or 3, n = 2 or 3, q = 0 or 1, R = H or unsubstituted or substituted hydrocarbon and pharmaceutically acceptable salts, provided that at least one CR2 group represents CO and forms, together with an adjacent N atom, a -CONR- amide group. |
申请人 |
AMERSHAM INTERNATIONAL PLC;ARCHER, COLIN, MILL;BOWER, GARY, ROBERT;GILL, HARJIT, KAUR;RILEY, ANTHONY, LEONARD, MARK;STOREY, ANTHONY, EAMON;CANNING, LEWIS, REUBEN;GRIFFITHS, DAVID, VAUGHAN |
发明人 |
ARCHER, COLIN, MILL;BOWER, GARY, ROBERT;GILL, HARJIT, KAUR;RILEY, ANTHONY, LEONARD, MARK;STOREY, ANTHONY, EAMON;CANNING, LEWIS, REUBEN;GRIFFITHS, DAVID, VAUGHAN |