SUPPRESION OF HIV EXPRESSION BY ORGANIC THIOPHOSPHATE

摘要

Chronic HIV infection is treated by administering to a subject an organic thiophosphate, a functional derivative or analogue thereof alone or in combination with another anti-HIV or anti-AIDS drug. The organic thiophosphate is preferably WR 151327, a compound with antioxidant and free radical scavenging activities, or a functional derivative or analogue thereof, preferably WR 151326. WR 151327 suppresses induction of HIV expression in chronically infected cells mediated by cytokines such as TNFα and GM-CSF. Pharmaceutical compositions comprising at least one organic thiophosphate in combination with one or more anti-HIV or anti-AIDS drugs are also disclosed.