发明名称 |
ANTIPSYCHOTIC BENZIMIDAZOLE DERIVATIVES |
摘要 |
A class of benzimidazole derivatives, substituted at the 2-position by a substituted piperazinylmethyl or piperazinylethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia whilst manifesting fewer side-effects than those associated with classical neuroleptic drugs. |
申请公布号 |
WO9422839(A1) |
申请公布日期 |
1994.10.13 |
申请号 |
WO1994GB00607 |
申请日期 |
1994.03.23 |
申请人 |
MERCK SHARP & DOHME LIMITED;KULAGOWSKI, JANUSZ, JOZEF;LEESON, PAUL, DAVID |
发明人 |
KULAGOWSKI, JANUSZ, JOZEF;LEESON, PAUL, DAVID |
分类号 |
A61K31/495;A61K31/496;A61P25/18;C07D235/14;C07D401/12;C07D403/12;C07D409/12;(IPC1-7):C07D235/14;A61K31/415 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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