POLYMERIC OPHTHALMIC LENS WITH CROSSLINKER CONTAINING SACCHARIDE RESIDUE

摘要

An ophthalmic lens, particularly a soft hydrogel contact lens, is disclosed. The lens can be derived from a crosslinked polymer made by reacting a hydrophilic monomer with a crosslinking amount of a polyfunctional compound containing a saccharide residue. The preferred hydrophilic monomer is actually a mixture of the following individual hydrophilic monomers: a) the reaction product of a free radical reactive monoisocyanate and a monoalkoxy polyalkylether, b) N,N-dimethylacrylamide, and optionally c)hydroxyethyl methacrylate. The preferred polyfunctional compound is a prepolymer derived from an alkoxylated glucose or sucrose. This prepolymer can be made by reacting glucose or sucrose, which has been ethoxylated or propoxylated, with a free radical reactive isocyanate which has been capped. The free radical reactive isocyanate can be capped by reacting it with a polyalkylether, such as polyethylene glycol, and then reacting this intermediate with a diisocyanate. Advantageously, a fluorinated monomer is added to the reactive components from which the crosslinked polymer of the lens is derived. The preferred fluoromonomer is composed of the reaction product of a free radical reactive monoisocyanate and perfluorooctanol. The polymerization is ideally carried out in the presence of an inert diluent, preferably the boric acid ester of polyethylene glycol 400.