| 摘要 |
<p>A method for parenteral administration of a drug substance comprising penetration of the skin or the mucosa of a human or an animal by a body of an appropriately formed solid pharmaceutical composition is disclosed. The body of the pharmaceutical composition may be needle-shaped so that it is possible to avoid any external penetration equipment when the composition is administered. The composition is preferably made by materials which are biodegradable such as, e.g., materials selected from the group consisting of inorganic salts such as, e.g., calcium, magnesium, bismuth and zinc salts; lipids; carbohydrates, such as, e.g., polysaccharides, sucrose, glucose, agarose, dextrin, cyclodextrin and mixtures thereof; proteins such as, e.g., gelatins, collagens, modified collagens, albumins, caseins and derivatives thereof, and mixtures thereof; natural polymers, synthetic polymers such as, e.g., poly-epsilon-aminocaproic acid, poly-isobutyric acid and derivatives thereof, polylactic acid and derivatives thereof, polyglycolic acid and derivatives thereof, poly(lactide-glycolide)-copolymers and derivatives thereof, polyesters, polyethylene glycols, polypropylene glycols, Pluronics®; and mixtures thereof. Especially gelatin has proved suitable as basic material. A drug delivery system comprising a body of a pharmaceutical composition and supporting means for facilitating the administration is also disclosed.</p> |
