发明名称 |
PERHYDROISOINDOLE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
摘要 |
Perhydroisoindole derivatives of general formula (I), wherein radicals R are phenyl radicals optionally 2- or 3-substituted by a halogen atom or a methyl radical; R1 is optionally substituted phenyl, cyclohexadienyl, naphthyl, indenyl or optionally substituted heterocyclyl; R2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino; and R3 is optionally 2-substituted phenyl; optionally salts thereof where applicable; and preparation thereof. Said derivatives are particularly useful as neurokinin A antagonists. |
申请公布号 |
WO9422822(A1) |
申请公布日期 |
1994.10.13 |
申请号 |
WO1994FR00371 |
申请日期 |
1994.04.01 |
申请人 |
RHONE-POULENC RORER S.A.;CRESPO, ANDRE;FARDIN, VERONIQUE;GUILLAUME, JEAN-MARC;MALLERON, JEAN-LUC;PEYRONEL, JEAN-FRANCOIS |
发明人 |
CRESPO, ANDRE;FARDIN, VERONIQUE;GUILLAUME, JEAN-MARC;MALLERON, JEAN-LUC;PEYRONEL, JEAN-FRANCOIS |
分类号 |
A61K31/40;A61K31/403;A61K31/4035;A61P1/00;A61P9/08;A61P11/00;A61P13/02;A61P15/00;A61P25/04;A61P29/00;A61P43/00;C07D209/44;C07D403/06;(IPC1-7):C07D209/44;C07D403/10 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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