发明名称 |
YEAST CELLS ENGINEERED TO PRODUCE PHEROMONE SYSTEM PROTEIN SURROGATES, AND USES THEREFOR |
摘要 |
Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturaton of alpha -factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system. |
申请公布号 |
WO9423025(A1) |
申请公布日期 |
1994.10.13 |
申请号 |
WO1994US03143 |
申请日期 |
1994.03.23 |
申请人 |
CADUS PHARMACEUTICALS, INC. |
发明人 |
FOWLKES, DANA, MERRIMAN;BROACH, JIM;MANFREDI, JOHN;KLEIN, CHRISTINE;MURPHY, ANDREW, J.;PAUL, JEREMY;TRUEHEART, JOSHUA |
分类号 |
C12N15/09;C07K14/395;C12N1/19;C12N15/81;C12P21/02;C12Q1/02;C12R1/865;G01N33/15;G01N33/50;(IPC1-7):C12N15/10;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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