发明名称 |
PROCESS FOR INHIBITING THE TRANSCRIPTION OF GENES |
摘要 |
Inhibition of the transcription of genes in higher eukaryotic cells by inhibiting the activation of NF-KB, wherein the cells are treated with substances which specifically inhibit the proteolytic degradation of IKB-.alpha. directly or indirectly. Process for screening substances which inhibit NF-KB activation by inhibiting the proteolytic degradation of IKB-.alpha.. Use of the substances for treating pathological conditions which can be traced back to undesirable gene expression controlled by NF-KB.
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申请公布号 |
CA2159822(A1) |
申请公布日期 |
1994.10.13 |
申请号 |
CA19942159822 |
申请日期 |
1994.03.31 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
BAEUERLE, PATRICK;HENKEL, THOMAS |
分类号 |
C12N15/09;A61K31/135;A61K31/22;A61K31/40;A61K38/00;A61K38/55;A61P43/00;C07K5/083;C07K14/47;C12N9/99;C12N15/85;C12Q1/68;(IPC1-7):C12Q1/68;A61K31/18;A61K31/325;A61K38/06;C07K5/08;C12Q1/37;C12Q1/66 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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