PYRAZOLE DERIVATIVES

摘要

Pyrazole compounds of formula ¢1! and their tautomers and salts: <IMG> ¢1! (wherein R1 is an alkyl group, etc.; R2 is a carboxyl group, etc.; R3 is a halogen atom, an alkyl group, a phenyl group, etc.; R4, R5 and R6 each are a hydrogen atom, a halogen atom, etc.; R7 is a carboxyl group, a 5-tetrazolyl group, etc.; X is a nitrogen atom, etc.; Y and Z each are CH, a nitrogen atom, etc.; A and E each are a methylene group, etc.; D is a phenyl group, etc.; G is a covalent bond, etc.). The compounds of the invention have an antagonistic effect against angiotensin II and are useful for prevention and remedy of hypertension, congestive cardiac insufficiency, chronic renal insufficiency, aldosteronism, hyper-intraocular pressure, etc.