发明名称 |
CHIMERIC DNA-RNA CATALYTIC SEQUENCES. |
摘要 |
<p>This invention provides chimeric DNA/RNA catalytic molecules useful to cleave RNA sequences. The invention specifically provides two different chimeric DNA-RNA-DNA-RNA-DNA catalytic molecules which are targeted to cleave HIV-1 RNA sequences. These chimeric molecules include DNA sequences which flank a catalytic RNA center. Interaction with the HIV-1 substrate RNA is achieved by Watson-Crick base pairing of the DNA flanking sequences with HIV-1 RNA. The catalytic ribonucleotide center cleaves the phosphodiester bond of the substrate HIV-1 RNA at the expected location. <IMAGE></p> |
申请公布号 |
EP0451221(B1) |
申请公布日期 |
1994.10.12 |
申请号 |
EP19900909257 |
申请日期 |
1990.06.05 |
申请人 |
CITY OF HOPE |
发明人 |
ROSSI, JOHN, J.;CHANG, PAIROJ;KAPLAN, BRUCE, E. |
分类号 |
C12N1/21;A61K38/00;B64D13/06;C07H15/12;C07H21/02;C12N1/13;C12N1/20;C12N9/00;C12N15/00;C12N15/09;C12N15/113;C12N15/31;C12N15/70;C12P19/34;C12P21/02;C12P21/04;C12P21/06;C12Q1/68;C12R1/19;F25B9/00;F25B11/04;(IPC1-7):A61K37/62;C07H17/00;A61K31/70 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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